The science

1. Placebo-controlled crossover trial

   Under mental load, 91.4% correct answers with tyrosine versus 86.5% with placebo.

   Colzato et al. · Frontiers in Behavioral Neuroscience · 2013 See the study

2. Review of studies

   Tyrosine may help maintain mental performance in short moments of stress or high demand.

   Jongkees et al. · Journal of Psychiatric Research · 2015 See the study

3. Controlled trial

   Better performance on memory and tracking tests during tough military training.

   Deijen et al. · Brain Research Bulletin · 1999 See the study

1. Placebo-controlled trial

   Same dose as Energy + Focus

   Fewer errors on a sustained attention test in 28 days. With 250 mg, also fewer omissions.

   McGlade et al. · Food and Nutrition Sciences · 2012 See the study

2. Placebo-controlled trial

   Better episodic memory and a better overall memory score than with placebo in 12 weeks.

   Nakazaki et al. · The Journal of Nutrition · 2021 See the study

3. Placebo-controlled trial

   Better attention and faster psychomotor speed than with placebo in 28 days.

   McGlade et al. · Journal of Attention Disorders · 2019 See the study

4. Brain imaging study

   Markers of cellular energy in the frontal lobe went up: phosphocreatine by 7% and ATP by 14%.

   Silveri et al. · NMR in Biomedicine · 2008 See the study

5. Brain imaging study

   7% more brain phosphodiesters, linked to neuronal membranes, associated with better verbal learning.

   Babb et al. · Psychopharmacology · 2002 See the study

1. Placebo-controlled trial

   Faster visual processing, better learning and more retention of what was learned in 12 weeks.

   Stough et al. · Psychopharmacology · 2001 See the study

2. Placebo-controlled trial

   New information was forgotten less than with placebo.

   Roodenrys et al. · Neuropsychopharmacology · 2002 See the study

3. Meta-analysis

   Across nine trials, bacopa improved mental performance, especially speed of attention.

   Kongkeaw et al. · Journal of Ethnopharmacology · 2014 See the study

4. Placebo-controlled trial

   Better verbal learning and better delayed recall than with placebo.

   Morgan and Stevens · J Altern Complement Med · 2010 See the study

5. Placebo-controlled trial

   Better spatial working memory and fewer false positives on a visual processing test.

   Stough et al. · Phytotherapy Research · 2008 See the study

6. Placebo-controlled trial

   Better working memory and better logical memory than with placebo in medical students.

   Kumar et al. · Evid Based Complement Alternat Med · 2016 See the study

7. Placebo-controlled trial

   Better delayed word recall and a better result on an attention test (Stroop).

   Calabrese et al. · J Altern Complement Med · 2008 See the study

8. Systematic review

   Memory improved in 9 of the 17 free recall tests analysed.

   Pase et al. · J Altern Complement Med · 2012 See the study

1. Placebo-controlled crossover trial

   Same dose as Energy + Focus

   With 200 mg a day, a better total score than with placebo on an attention test (Stroop) in 7 days.

   Koozehchian et al. · Nutrients · 2025 See the study

2. Crossover trial

   Improved a mental fatigue index based on five tests during the first two weeks of night shifts.

   Darbinyan et al. · Phytomedicine · 2000 See the study

3. Placebo-controlled trial

   With a single dose, more capacity for mental work under fatigue than with placebo.

   Shevtsov et al. · Phytomedicine · 2003 See the study

4. Placebo-controlled pilot study

   Less mental fatigue and greater general well-being than with placebo during exam period.

   Spasov et al. · Phytomedicine · 2000 See the study

5. Systematic review

   Eleven placebo-controlled trials point to benefits in physical and mental performance, with few side effects.

   Hung, Perry and Ernst · Phytomedicine · 2011 See the study

1. Placebo-controlled crossover trial

   With a single 200 mg dose, better mental arithmetic and less feeling of mental fatigue in repeated demanding tasks.

   Reay, Kennedy and Scholey · Journal of Psychopharmacology · 2005 See the study

2. Placebo-controlled crossover trial

   Better memory and more accurate attention after a single dose.

   Kennedy, Scholey and Wesnes · Physiology & Behavior · 2002 See the study

1. Review of studies

   Between 40 and 300 mg, caffeine improves alertness, vigilance, attention and reaction time.

   McLellan et al. · Neuroscience & Biobehavioral Reviews · 2016 See the study

2. Review of studies

   Caffeine improves alerting attention and executive control, and the effect is not explained by relieving withdrawal.

   Einöther and Giesbrecht · Psychopharmacology · 2013 See the study

3. Placebo-controlled trial

   Slow-release caffeine maintained vigilance and performance in sleep-deprived people, at doses of 150 to 600 mg.

   Lagarde et al. · Sleep · 2000 See the study

1. Meta-analysis

   Across 13 trials and 1,126 people, coenzyme Q10 reduced tiredness versus placebo.

   Tsai et al. · Frontiers in Pharmacology · 2022 See the study

2. Placebo-controlled trial

   Less fatigue and less sleepiness after mental tasks.

   Mizuno et al. · Nutrients · 2020 See the study

3. Placebo-controlled crossover trial

   With 300 mg, a better sprint at the end of a long cycling test and less feeling of tiredness.

   Mizuno et al. · Nutrition · 2008 See the study

1. Placebo-controlled trial

   Same dose as Energy + Focus

   With 120 mg of coenzyme Q10 a day, around 30% more in the blood after 21 days when 5 mg of piperine was added.

   Badmaev, Majeed and Prakash · Journal of Nutritional Biochemistry · 2000 See the study

Contributes to the reduction of tiredness and fatigue. Claim authorised in the EU.

1. EFSA scientific opinion

   Vitamin B12 contributes to the reduction of tiredness and fatigue and to normal psychological function.

   EFSA NDA Panel · EFSA Journal · 2010 See the source

2. EFSA scientific opinion

   Vitamin B12 contributes to normal energy-yielding metabolism.

   EFSA NDA Panel · EFSA Journal · 2009 See the source

3. EU regulation

   Claims authorised in the EU for foods that are at least a source of vitamin B12. One daily serving of Energy + Focus provides 100% of the reference intake.

   European Commission · 2012 See the source